Journal of Clinical Immunology and Allergy

Peritoneal Mast Cell Stabilization Potential of Ziziphus Xylopyrus (Retz) Wild Extract in Rat Mesenteric Model

Objective: To investigate the peritoneal mast cell stabilization activity of Ziziphus xylopyrus extracts.

Materials and Methods: Ziziphus Xylopyrus L. (family- Rhamnaceae) stem part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of Ziziphus Xylopyrus (Z. xylopyrus) were evaluated for stabilization of mast cell in rat for the evaluation of Hypersensitivity type I allergic reaction in animal models. The extract of Z. xylopyrus ethanolic and aqueous (1, 10 and 100 μg/ml) was evaluated for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80.

Result: Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic and aqueous extracts of Z. xylopyrus showed dose dependent increase in the number of intact cells when compare with C 48/80 at the concentration of 10 and 100 μg/ml. It virtues further work towards the isolation of phyto constituents from this plant.

Conclusion: This finding provides evidence that the Z. xylopyrus inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. Z. xylopyrus has a potential as allergic anti-asthmatic agent.

Author(s):

Saurabh Gupta,K. Rama Satyanarayana Raju,Shashank Mulukutla, Nilesh Ambhore,Yamini Parmar,Swati Khare,Vidhi Sharma,Richa Pathak,Paramjeet Devda and Tagis Mehar

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