The role of interleukin 33 in patients with allergic diseases who has a positive result of total and specific IgE

Introduction: Allergic diseases affect a large group of population and the common types were asthma, rhinitis, and urticaria and newly found that IL-33 playing an important role in the pathogenicity of allergic diseases.

Objectives: The main goal of this research to evaluate the levels of IL-33 in adult patients has real allergic diseases (asthma, rhinitis, and urticaria) through the detection of both positive assays of total and specific IgE of allergic diseases.

Methods: The total and specific immunoglobulin E (IgE) and IL-33 were determined in the serum of three types of allergic patients and healthy controls.

Results: There was a highly significantly higher concentration of IgE and IL- 33 in the serum of patients with allergic diseases. Serum IL-33 and total IgE concentration are clearly statistically highly significant increases in three groups of patients (Rhinitis, Asthma, Urticaria) compared with healthy control (p< 0.001). No significant correlation between IL-33 levels and total IgE in four groups.

Conclusion: Our results show a significantly higher concentration in serum level IL- 33 of patients with three types of allergic diseases (asthma, rhinitis, and urticaria).


interleukin 33, allergic diseases, specific IgE.


Ghanyia Jasim Shanyoor

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